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|Title:||1 and 2 adrenoceptor mediated melanosome aggregatory responses in vitro in Oreochromis mossambica (Peters) melanophores|
|Authors:||Acharya, L. Shobha Kumari|
|Keywords:||1, 2 adrenoceptors;Melanophore;Oreochromis mossambica|
|Abstract:||Effects of specific and non-specific adrenoceptor agonists and antagonists were examined on the isolated scale melanophores of O. mossambica in physiological Ringer solution. The responses were recorded as melanophore size index. It was observed that adrenaline, nor-adrenaline, phenylpropanolamine, clonidine and phenylepherine induced melanosome aggregation in a dose-dependent manner. Denervation of the fish melanophores increased the sensitivity of the melanophores to adrenaline but not to nor-adrenaline. Phentolamine (3.5510-5 M), prazosin (2.3810-5 M) and yohimbine (2.82110-5 M) significantly inhibited the aggregatory responses of the fish melanophores to adrenaline, nor-adrenaline, clonidine and phenylepherine. The blocking effect of yohimbine was significantly higher than that of prazosin. It is concluded that the effect of adrenaline is directly mediated through the receptors and 2 adrenoceptors are predominantly involved in the aggregatory responses of this fish melanophores, while 1 adrenoceptors presence has been indicated.|
|ISSN:||0975-1009 (Online); 0019-5189 (Print)|
|Appears in Collections:||IJEB Vol.45(11) [November 2007]|
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