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dc.contributor.authorSingh, Sonia-
dc.contributor.authorSemwal, Bhupesh C.-
dc.identifier.issn0976-0512 (Online); 0976-0504 (Print)-
dc.description.abstractThe present study was designed to investigate the protective effect of methanol extract of S. indicus L. leaves (SIME) on seizures using pentylenetetrazole (PTZ) and maximal electroshock (MES) models in mice. The methanol extract was obtained by maceration process of 500g leaves with methanol at room temperature for 72 hours. In MES model, the prevention of hind limb extension was considered as a protective action. In the PTZ induced seizure model, the presence or absence of clonic convulsion was considered as the endpoint. The extraction obtained were evaluated for antioxidant activity using free radical scavenging activity. The extract at a dose of 300 mg/kg b.w, p.o, resulted significant (P <0.0001) antiepileptic activity by decreasing the duration of hind limb extension phase in MES model and delaying the onset of action in PTZ model with the control and other test groups. The SIME scavenged DPPH radical, by showing IC50= 25.68 µg/mL and exhibit significant result (P <0.0001) at a dose of 300 mg/kg. The biochemical evaluation of SLME showed a significant increase (300 mg/kg) in the amount of GABA level brain against PTZ induced seizures in mice. The methanol extract of S. indicus L. leaves has antiepileptic activity, which might be because of flavonoids.en_US
dc.publisherNISCAIR-CSIR, Indiaen_US
dc.relation.ispartofseriesInt. cl. (2015.01) –A61K 36/00, A61K 36/28, A61K 127/00, A61P 25/08, A61P 39/06en_US
dc.rights CC Attribution-Noncommercial-No Derivative Works 2.5 Indiaen_US
dc.sourceIJNPR Vol.10(3) [September 2019]en_US
dc.subjectMethanol extracten_US
dc.titleProtective effect of methanol leaf extract of Sphaeranthus indicus L. on an experimental model of epilepsyen_US
Appears in Collections:IJNPR Vol.10(3) [September 2019]

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