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IJEB Vol.45(10) [October 2007] >


Title: Effect of glucocorticoid on protein and creatine content of inactivated muscle of rats
Authors: Mandal, Salil Kumar
Keywords: Creatine
Denervation
Gastrocnemius weight
Glucocorticoid
Prednisolone
Protein
Tenotomy
Issue Date: Oct-2007
Publisher: CSIR
Abstract: In denervation, there was loss of protein in gastrocnemius muscles and this loss of was more in prednisolone treated animals. There was significant change of protein loss between tenotomy and tenotomy with prednisolone treatment. The reduction of protein in denervation and denervation with prednisolone treatment were also highly significant. Significant loss of muscle creatine was observed in denervation with prednisolone treatment. It was about 50% of the normal control group and about 40% when compared to other limb. In denervation alone, the creatine loss was about 24%. In tenotomy and in tenotomy with prednisolone treatment, the loss of creatine was also significantly high. All these figures regarding the reduction of muscle creatine in different experiments were highly significant. The reduction of muscle weight, protein and creatine content of muscle in denervation were due to inactivation of the muscle and due to trophic changes caused by loss of motor supply to the muscle. But in tenotomy, the reductions were only due to inactivation.
Page(s): 907-910
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Source:IJEB Vol.45(10) [October 2007]

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