Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/5340
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dc.contributor.authorGilhotra, Neeraj-
dc.contributor.authorSharma, Ajay-
dc.contributor.authorSingh, Manjeet-
dc.contributor.authorDhingra, Dinesh-
dc.date.accessioned2009-07-20T07:15:07Z-
dc.date.available2009-07-20T07:15:07Z-
dc.date.issued2007-07-
dc.identifier.issn0975-1009 (Online); 0019-5189 (Print)-
dc.identifier.urihttp://hdl.handle.net/123456789/5340-
dc.description654-656en_US
dc.description.abstractExperimental diabetes induced by streptozotocin (200 mg/kg, ip) markedly decreased the antinociceptive effect of morphine and significantly increased the urinary nitrite concentration. Administration of FR-167653 (a selective p38MAPKinase inhibitor) in a dose of 4 mg/kg improved the antinociceptive effect of morphine and attenuated the increase in urinary nitrite concentration in diabetic mice. It may be concluded that diabetes-induced decrease in antinociceptive effect of morphine may be due to induction of p38 MAPKinase activity.en_US
dc.language.isoen_USen_US
dc.publisherCSIRen_US
dc.sourceIJEB Vol.45(07) [July 2007]en_US
dc.subjectAntinociceptionen_US
dc.subjectDiabetesen_US
dc.subjectFR-167653en_US
dc.subjectMorphineen_US
dc.subjectp38MAPKinaseen_US
dc.titleInvolvement of p38 MAPkinase in attenuation of antinociceptive effect of morphine in diabetic miceen_US
dc.typeArticleen_US
Appears in Collections:IJEB Vol.45(07) [July 2007]

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