Please use this identifier to cite or link to this item:
|Title:||Involvement of p38 MAPkinase in attenuation of antinociceptive effect of morphine in diabetic mice|
|Abstract:||Experimental diabetes induced by streptozotocin (200 mg/kg, ip) markedly decreased the antinociceptive effect of morphine and significantly increased the urinary nitrite concentration. Administration of FR-167653 (a selective p38MAPKinase inhibitor) in a dose of 4 mg/kg improved the antinociceptive effect of morphine and attenuated the increase in urinary nitrite concentration in diabetic mice. It may be concluded that diabetes-induced decrease in antinociceptive effect of morphine may be due to induction of p38 MAPKinase activity.|
|ISSN:||0975-1009 (Online); 0019-5189 (Print)|
|Appears in Collections:||IJEB Vol.45(07) [July 2007]|
Items in NOPR are protected by copyright, with all rights reserved, unless otherwise indicated.