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Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.45 [2007] >
IJEB Vol.45(07) [July 2007] >
| Title: | Involvement of p38 MAPkinase in attenuation of antinociceptive effect of morphine in diabetic mice |
| Authors: | Gilhotra, Neeraj
Sharma, Ajay
Singh, Manjeet
Dhingra, Dinesh |
| Keywords: | Antinociception
Diabetes
FR-167653
Morphine
p38MAPKinase |
| Issue Date: | Jul-2007 |
| Publisher: | CSIR |
| Abstract: | Experimental diabetes induced by streptozotocin (200 mg/kg, ip) markedly decreased the antinociceptive effect of morphine and significantly increased the urinary nitrite concentration. Administration of FR-167653 (a selective p38MAPKinase inhibitor) in a dose of 4 mg/kg improved the antinociceptive effect of morphine and attenuated the increase in urinary nitrite concentration in diabetic mice. It may be concluded that diabetes-induced decrease in antinociceptive effect of morphine may be due to induction of p38 MAPKinase activity. |
| Page(s): | 654-656 |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.45(07) [July 2007]
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