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IJEB Vol.45(07) [July 2007] >


Title: Involvement of p38 MAPkinase in attenuation of antinociceptive effect of morphine in diabetic mice
Authors: Gilhotra, Neeraj
Sharma, Ajay
Singh, Manjeet
Dhingra, Dinesh
Keywords: Antinociception
Diabetes
FR-167653
Morphine
p38MAPKinase
Issue Date: Jul-2007
Publisher: CSIR
Abstract: Experimental diabetes induced by streptozotocin (200 mg/kg, ip) markedly decreased the antinociceptive effect of morphine and significantly increased the urinary nitrite concentration. Administration of FR-167653 (a selective p38MAPKinase inhibitor) in a dose of 4 mg/kg improved the antinociceptive effect of morphine and attenuated the increase in urinary nitrite concentration in diabetic mice. It may be concluded that diabetes-induced decrease in antinociceptive effect of morphine may be due to induction of p38 MAPKinase activity.
Page(s): 654-656
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Source:IJEB Vol.45(07) [July 2007]

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