NISCAIR Online Periodicals Repository

NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR)  >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.45 [2007] >
IJEB Vol.45(07) [July 2007] >


Title: Comparative interaction of few antihypertensive drugs with Cyclosporine-A in rats
Authors: Kumar, N Prem
Inamdar, M N
Venkataraman, B V
Keywords: Cyclosporin-A
Diltiazem
Enalapril
Hypertension
Losartan
Propranolol
Thoracic aorta
Issue Date: Jul-2007
Publisher: CSIR
Abstract: The maximal endothelial dependent relaxation of isolated aortic rings to cumulative doses of acetylcholine was significantly decreased in the Cyclosporine-A (CSA, 20 mg kg-1 day-1) treated animals compared to olive oil (CSA vehicle) treated control. Administration of antihypertensive drugs like diltiazem, enalapril or propranolol to CSA treated animals augmented the endothelial damage induced by CSA. These drugs also increased the bioavailability of CSA. However, administration of losartan to CSA treated animals produced a significant increase in endothelial dependent relaxation as compared to CSA treated control but did not affect the bioavailability of CSA significantly. The results suggest that losartan is safer compared to other antihypertensives for the treatment of CSA induced hypertension.
Page(s): 638-641
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Source:IJEB Vol.45(07) [July 2007]

Files in This Item:

File Description SizeFormat
IJEB 45(7) 638-641.pdf78.09 kBAdobe PDFView/Open
 Current Page Visits: 541 
Recommend this item

 

National Knowledge Resources Consortium |  NISCAIR Website |  Contact us |  Feedback

Disclaimer: NISCAIR assumes no responsibility for the statements and opinions advanced by contributors. The editorial staff in its work of examining papers received for publication is helped, in an honorary capacity, by many distinguished engineers and scientists.

CC License Except where otherwise noted, the Articles on this site are licensed under Creative Commons License: CC Attribution-Noncommercial-No Derivative Works 2.5 India

Copyright © 2012 The Council of Scientific and Industrial Research, New Delhi. All rights reserved.

Powered by DSpace Copyright © 2002-2007 MIT and Hewlett-Packard | Compliant to OAI-PMH V 2.0

Home Page Total Visits: 510650 since 06-Feb-2009  Last updated on 11-Apr-2014Webmaster: nopr@niscair.res.in