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Title: Effects of angiotensin II and captopril on rewarding propreties of morphine
Authors: Hosseini, Mahmoud
Sharifi, Mohammad Reza
Alaei, Hojatallah
Shafei, Mohammad Naser
Karimooy, Habib Allah Nemati
Keywords: Angiotensin II;Captopril;CPP;Morphine;Rat;Self-administration
Issue Date: Sep-2007
Publisher: CSIR
Abstract: The effects of captopril and Ang II on morphine-induced conditioned place preference (CPP) and morphine self- administration in male Wistar rat were investigated. In CPP experiment, injection of captopril before test significantly decreased the difference of the time spent in compartment A between pre- and post-conditioning compared to morphine group. In self- administration experiment number of active lever pressing was significantly greater than passive in morphine group. In captopril group number of active lever pressing was significantly lower than morphine group however, there was not significant difference between active and passive lever pressed number. The results showed that captopril significantly decreased morphine-induced conditional place preference and morphine self-administration but the effect of Ang II was not significant. It can be concluded that RAS may have a role in rewarding properties of morphine.
Page(s): 770-777
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.45(09) [September 2007]

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