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|Title:||Protective effect of <i style="">Aquilegia vulgaris</i> (L.) on carbon tetrachloride-induced oxidative stress in rats|
<i style="">Aquilegia vulgaris</i>
Microsomal lipid peroxidation
|Abstract:||The ethyl ether extract of <i style="">A. vulgaris</i> inhibited <i style="">in vitro</i> microsomal lipid peroxidation (IC<sub>50</sub> 58.8 µg/ml) and showed moderate ability to scavenge superoxide radicals and to chelate iron ions. The extract (100 mg/kg body weight, po) decreased uninduced and enzymatic microsomal lipid peroxidation in the liver of male rats pretreated with CCl<sub>4</sub> (1 ml/kg body weight) by 27 and 40%, respectively. Activity of antioxidant and related enzymes (catalase and glucose-6-phosphate dehydrogenase) inhibited by CCl<sub>4</sub> was significantly restored after administration of the extract. The extract itself significantly enhanced superoxide dismutase activity. There was no effect of the extract on hepatic glutathione level and cytochrome P450 content, both were decreased by CCl<sub>4</sub>. Neither CCl<sub>4</sub> nor the tested extract affected activities of NADPH-cytochrome P450 reductase and two monooxygenases, aniline hydroxylase and aminopyrine n-demethylase. It can be concluded that the protective effect of the <i style="">A. vulgaris</i> extract in CCl<sub>4</sub>-induced liver injury is mediated by inhibition of microsomal lipid peroxidation and restoring activity of some antioxidant and related enzymes.|
|ISSN:||0975-1009 (Online); 0019-5189 (Print)|
|Appears in Collections:||IJEB Vol.45(08) [August 2007]|
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