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IJEB Vol.45(08) [August 2007] >


Title: Protective effect of Aquilegia vulgaris (L.) on carbon tetrachloride-induced oxidative stress in rats
Authors: Kujawska, Malgorzata
Jodynis-Liebert, Jadwiga
Ewertowska, Malgorzata
Adamska, Teresa
Matlawska, Irena
Bylka, Wieslawa
Keywords: Antioxidant enzymes
Aquilegia vulgaris
CCl4
Glutathione
Microsomal lipid peroxidation
Issue Date: Aug-2007
Publisher: CSIR
Abstract: The ethyl ether extract of A. vulgaris inhibited in vitro microsomal lipid peroxidation (IC50 58.8 µg/ml) and showed moderate ability to scavenge superoxide radicals and to chelate iron ions. The extract (100 mg/kg body weight, po) decreased uninduced and enzymatic microsomal lipid peroxidation in the liver of male rats pretreated with CCl4 (1 ml/kg body weight) by 27 and 40%, respectively. Activity of antioxidant and related enzymes (catalase and glucose-6-phosphate dehydrogenase) inhibited by CCl4 was significantly restored after administration of the extract. The extract itself significantly enhanced superoxide dismutase activity. There was no effect of the extract on hepatic glutathione level and cytochrome P450 content, both were decreased by CCl4. Neither CCl4 nor the tested extract affected activities of NADPH-cytochrome P450 reductase and two monooxygenases, aniline hydroxylase and aminopyrine n-demethylase. It can be concluded that the protective effect of the A. vulgaris extract in CCl4-induced liver injury is mediated by inhibition of microsomal lipid peroxidation and restoring activity of some antioxidant and related enzymes.
Page(s): 702-711
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Source:IJEB Vol.45(08) [August 2007]

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