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Title: Cell adhesion by aqueous extract of human placenta used as wound healer
Authors: Nath, Sangeeta
Bhattacharyya, Debasish
Keywords: Anti-β<sub>1 </sub>integrin
Cell adhesion
Human placental extract
RDG peptide
Issue Date: Aug-2007
Publisher: CSIR
Abstract: Aqueous extract of human placenta, used as wound healer, has shown significant cell adhesion property on mouse peritoneal macrophages and P<sub>388D1 </sub>cultured macrophage cell line. This property was offered primarily by fibronectin type III like peptide present in the extract and is comparable to fibronectin on a molar basis. The peptide induce adhesion of cell through cell surface receptors having K<sub>d</sub> = 2.8±0.9 x 10<sup>-5</sup> <i style="">M</i> suggesting weak binding. This is in support of integrins receptors that typically exhibit low affinities. Cell adhesion was partially inhibited by Arg-Gly-Asp (RGD) peptide, anti-β<sub>1 </sub>integrin suggesting that integrin β<sub>1 </sub>receptors have roles to play in the process.
Description: 732-738
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.45(08) [August 2007]

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