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Title: Phytochemical investigation and cytotoxic activity of hydro alcoholic fraction of Trianthema decandra
Authors: Gajjala, Kalpana
Anisetti, Ravindernath
Dodla, Jaya Prakash
Rathod, Aravind Kumar
Keywords: Trianthema decandra;HeLa;HepG2;MCF-7;MTT assay;GC-MS;Cytotoxic
Issue Date: Jul-2019
Publisher: NISCAIR-CSIR, India
Abstract: The objective of our study was to perform phytochemical analysis and evaluate for cytotoxic activity of hydro alcoholic fraction (H1) of Trianthema decandra L. (Aizoaceae) against breast, liver and cervical cancers. Hydro alcoholic fraction was separated from methanolic extract, which was prepared by maceration method from aerial parts of T. decandra The GC-MS analysis confirms the presence of seventeen bioactive compounds which belongs to carbohydrates, terpenoids, alkaloids, cardiac glycosides, fatty acids and their esters or alcohols, and their presence were supported with Fourier Transform Infrared Spectroscopy (FT-IR) and preliminary phytochemical analysis. Most of the compounds are biologically active and are known to exhibit antimicrobial and cancer preventive properties. Hydro alcoholic fraction was subjected to morphological evaluation and MTT cell viability assay. It has exhibited significant cytotoxic activity and their IC50 values were determined as 165.22 + 1.53 mg/ml, 175.28 + 1.7 mg/ml and 201.93 + 1.33 mg/ml against MCF-7, HeLa and HepG2 cancer cells, respectively. This bioactive fraction has exhibited cytotoxicity relatively more against breast cancer than cervical and liver cancers.
Page(s): 193-203
ISSN: 0975-0967 (Online); 0972-5849 (Print)
Appears in Collections:IJBT Vol.18(3) [July 2019]

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