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Title: A practical large scale synthesis of nimesulide — A step ahead
Authors: Prasad, Ashok
Sharma, M L
Kanwar, Seema
Rathee, Raman
Sharma, S D
Keywords: Nimesulide
Large-scale synthesis
COX-2 selective drug
Issue Date: Oct-2005
Publisher: CSIR
IPC CodeA61P
Abstract: Nimesulide, a COX-2 selective drug, possesses anti-inflammatory and analgesic properties. Moreover, it has low gastro-intestinal and renal toxicity. This paper presents industrially viable, new and improved synthesis of nimesulide starting from o-chloro nitrobenzene. The reaction with triphenyl phosphate yields 2-phenoxy nitrobenzene (90%) followed by reduction and mesylation and finally selective nitration furnishes the drug (85%).
Page(s): 756-760
ISSN: 0975-1084 (Online); 0022-4456 (Print)
Source:JSIR Vol.64(10) [October 2005]

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