|
NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR) >
NISCAIR PUBLICATIONS >
Research Journals >
Journal of Scientific and Industrial Research (JSIR) >
JSIR Vol.64 [2005] >
JSIR Vol.64(10) [October 2005] >
| Title: | A practical large scale synthesis of nimesulide — A step ahead |
| Authors: | Prasad, Ashok
Sharma, M L
Kanwar, Seema
Rathee, Raman
Sharma, S D |
| Keywords: | Nimesulide
Large-scale synthesis
COX-2 selective drug |
| Issue Date: | Oct-2005 |
| Publisher: | CSIR |
| IPC Code: | A61P |
| Abstract: | Nimesulide, a COX-2 selective drug, possesses anti-inflammatory and analgesic properties. Moreover, it has low gastro-intestinal and renal toxicity. This paper presents industrially viable, new and improved synthesis of nimesulide starting from o-chloro nitrobenzene. The reaction with triphenyl phosphate yields 2-phenoxy nitrobenzene (90%) followed by reduction and mesylation and finally selective nitration furnishes the drug (85%).
 |
| Page(s): | 756-760 |
| ISSN: | 0975-1084 (Online); 0022-4456 (Print) |
| Source: | JSIR Vol.64(10) [October 2005]
|
|
