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IJEB Vol.45(06) [June 2007] >


Title: Antinociceptive effect of amitriptyline in mice of acute pain models
Authors: Paudel, Keshab Raj
Das, Balbhadra Prasad
Rauniar, G P
Sangraula, Himal
Deo, Satish
Bhattacharya, S K
Keywords: Acute pain
Amitriptyline
Antinociception
Mice
Issue Date: Jun-2007
Publisher: CSIR
Abstract: Tricyclic antidepressant drugs induce antinociceptive effect and suggest that their analgesic action could be related to the monoaminergic activity of the drugs. The analgesic activity of amitriptyline was observed in mouse models of acute pain. Mice were divided into different groups and were given amitriptyline in different doses alone and in combination with morphine. Reaction time in Hot-Plate and Tail-Flick tests was observed. Results showed that amitriptyline had antinociceptive effect in acute pain state in experimental models. Amitriptyline in combination with morphine had better analgesic effect than the morphine alone in Hot-Plate test.
Page(s): 529-531
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Source:IJEB Vol.45(06) [June 2007]

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