Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/5275
Title: Cardiotonic activity of aqueous extract of heartwood of <i style="">Pterocarpus marsupium</i>
Authors: Mohire, N C
Salunkhe, V R.
Bhise, S B
Yadav, A V
Keywords: IFHP
<i style="">P. marsupium</i>
Digoxin
<i style=""> </i>Therapeutic window
Issue Date: Jun-2007
Publisher: CSIR
Abstract: The present study was undertaken to evaluate cardiotonic activity of aqueous extract of heartwood of <i style="">P. marsupium.</i> This plant species contains 5,7,2-4 tetrahydroxy isoflavone 6-6 glucoside which are potent antioxidant and are believed to prevent cardiovascular diseases. Cardiotonic effect of aqueous extract of heartwood of <i style="">P. marsupium </i>was studied by using isolated frog heart perfusion technique (IFHP). Calcium free Ringer solution was used as vehicle for administration of aqueous extract of <i style="">P. marsupium</i> as a test extract and digoxin as a standard. A significant increase in height of force of contraction (positive inotropic effect) and decrease in heart rate (negative chronotropic effect) at a very low concentration (0.25 mg/ml) was observed with test extract as compared to the same dose of a standard digoxin. The present results indicated that a significant increase in height of force of contraction with decrease in heart rate was observed as the dose of test extract increased. The test extract produced cardiac arrest at 4 mg/ml, a higher concentration, as compared to standard, digoxin (0.5 mg/ml). Compared to digoxin, a drug with narrow therapeutic window, <i style="">P. marsupium</i> showed wide therapeutic window.
Description: 532-537
URI: http://hdl.handle.net/123456789/5275
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.45(06) [June 2007]

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