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|Title:||Cardiotonic activity of aqueous extract of heartwood of <i style="">Pterocarpus marsupium</i>|
|Authors:||Mohire, N C|
Salunkhe, V R.
Bhise, S B
Yadav, A V
<i style="">P. marsupium</i>
<i style=""> </i>Therapeutic window
|Abstract:||The present study was undertaken to evaluate cardiotonic activity of aqueous extract of heartwood of <i style="">P. marsupium.</i> This plant species contains 5,7,2-4 tetrahydroxy isoflavone 6-6 glucoside which are potent antioxidant and are believed to prevent cardiovascular diseases. Cardiotonic effect of aqueous extract of heartwood of <i style="">P. marsupium </i>was studied by using isolated frog heart perfusion technique (IFHP). Calcium free Ringer solution was used as vehicle for administration of aqueous extract of <i style="">P. marsupium</i> as a test extract and digoxin as a standard. A significant increase in height of force of contraction (positive inotropic effect) and decrease in heart rate (negative chronotropic effect) at a very low concentration (0.25 mg/ml) was observed with test extract as compared to the same dose of a standard digoxin. The present results indicated that a significant increase in height of force of contraction with decrease in heart rate was observed as the dose of test extract increased. The test extract produced cardiac arrest at 4 mg/ml, a higher concentration, as compared to standard, digoxin (0.5 mg/ml). Compared to digoxin, a drug with narrow therapeutic window, <i style="">P. marsupium</i> showed wide therapeutic window.|
|ISSN:||0975-1009 (Online); 0019-5189 (Print)|
|Appears in Collections:||IJEB Vol.45(06) [June 2007]|
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