Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/5270
Title: Involvement of adenosinergic receptors in anxiety related behaviours
Authors: Kulkarni, Shrinivas K
Singh, Kulwinder
Bishnoi, Mahendra
Keywords: Adenosine;Caffeine;Zero maze
Issue Date: May-2007
Publisher: CSIR
Abstract: In the present study, the effect of adenosine (A1 and A2 receptor agonist), caffeine (A2A receptor antagonist), theophylline (A2A receptor antagonist) and their combination was studied in anxiety related behaviours using elevated zero maze and elevated plus maze paradigms and compared their various behavioural profiles. Adenosine (10, 25, 50,100 mg/kg) significantly showed anxiolytic effect at all the doses, whereas caffeine (8, 15, 30, 60 mg/kg) and theophylline (30, 60 mg/kg) showed psychostimulatory action at lower doses and anxiogenic effect at higher doses. Pretreatment with caffeine (8, 15, 30 mg/kg) and theophylline (30 mg/kg) reversed the anxiolytic effect of adenosine. The study suggested the involvement of adenosinergic receptor system in anxiety related behaviours.
Page(s): 439-443
URI: http://hdl.handle.net/123456789/5270
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.45(05) [May 2007]

Files in This Item:
File Description SizeFormat 
IJEB 45(5) 439-443.pdf162.97 kBAdobe PDFView/Open


Items in NOPR are protected by copyright, with all rights reserved, unless otherwise indicated.