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Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.45 [2007] >
IJEB Vol.45(05) [May 2007] >
| Title: | Effects of paraquat on anti-oxidant system in rats |
| Authors: | Ray, Sanhita
Sengupta, Arnab
Ray, Amitabha |
| Keywords: | Anti-oxidants
Glutathione
Oxidative stress
Paraquat
Rat tissues |
| Issue Date: | May-2007 |
| Publisher: | CSIR |
| Abstract: | The toxic effects of paraquat on the anti-oxidant defense system of male albino rats were evaluated, after administering either a single dose (1.5 and 7.5 mg/kg of body weight) or continuous daily doses (same as above, i.e., 1.5 mg/kg and 7.5 mg/kg of body weight) for 3 and 7 days. Glutathione levels in blood cells, liver, lung and kidney tissues decreased in a dose and time dependent manner. Glutathione reductase and glucose-6-phosphate dehydrogenase activity decreased, whereas the activity of glutathione-S-transferase, glutathione peroxidase, catalase and superoxide dismutase increased in paraquat exposure. Malondialdehyde formation also increased in a dose and time dependent manner. The alterations of anti-oxidant system particularly glutathione can be utilized as biomarkers during management of paraquat poisoning. |
| Page(s): | 432-438 |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.45(05) [May 2007]
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