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Title: Mechanism of spasmolytic activity of a fraction of Sarcostemma brevistigma Wight
Authors: Kumar, P Suresh
Soni, K
Jadhav, S R
Doshi, N S
Saraf, M N
Keywords: Asclepiadaceae
Calcium channel antagonism
Sarcostemma brevistigma
Smooth muscle relaxant
Issue Date: May-2007
Publisher: CSIR
Abstract: The effect of chloroform soluble fraction (F-A) of twigs of Sarcostemma brevistigma on contractions induced by KCl, histamine, and acetylcholine in the isolated guinea pig ileum and taenia coli smooth muscles has been evaluated. F-A (19.5 µg/ml) significantly inhibited the contraction induced by 40 mM KCl to the extent of 87.6% in the isolated guinea pig ileum. In the isolated guinea pig ileum, F-A (64.3 and 59.2 µg/ml) significantly inhibited the contractions induced by acetylcholine and histamine to the extent of 85 and 83% respectively. In the isolated guinea pig taenia coli, F-A (65.2 µg/ml) significantly inhibited the contraction induced by 40 mM KCl to the extent of 96.0%. The inhibitory effect of F-A (40 µg/ml) on the isolated guinea pig taenia coli was reduced by Bay K 8644 (10-6M) to the extent of 61.6 from 73.6%. These results suggest that the F-A may exhibit smooth muscle relaxant activity by blocking the Ca2+ channels.
Page(s): 419-424
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Source:IJEB Vol.45(05) [May 2007]

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