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Title: Caffeine: A green, natural and biodegradable catalyst for convenient and expedient eco-safe synthesis of 1H-pyrazolo [1,2-b] phthalazine-5,10-dione derivatives under solvent-free conditions
Authors: Mohamadpour, Farzaneh
Keywords: Caffeine;Naturally green;Biodegradable catalyst;1H-pyrazolo [1,2-b] phthalazine-5,10-dione derivatives;Eco-safe procedure;Solvent-free conditions
Issue Date: Dec-2019
Publisher: NISCAIR-CSIR, India
Abstract: A green, convenient, highly versatile and solvent-free synthetic route for caffeine catalyzed one-pot multi-component synthesis of biologically active 1H-pyrazolo [1,2-b] phthalazine-5,10-dione derivatives via one-pot four-component condensation reaction of phthalimide, hydrazine monohydrate, aryl aldehydes and malononitrile has been studied. The green, natural, biodegradable and inexpensive catalyst, eco-safe reaction, solvent-free conditions, avoidance of hazardous or toxic catalysts, simplicity of operation and work-up procedures with no necessity of chromatographic purification steps, the availability and ease of handling of this solid catalyst and good to high yields are the notable benefits for the highly efficient synthesis of these products.
Page(s): 1398-1406
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.58B(12) December 2019]

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