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|Title:||One-pot two-step facile synthesis of new 6,7-dihydro-1H—pyrazolo [3,4-b] pyridine-5- carbonitrile hybrids as antimicrobial agents|
|Keywords:||Substituted aroyl/aroyloxymethyl;Schiff base;Pyrazolin;Pyridine;Carbonitrile;Antimicrobial;Antibacterial activity;Antifungal activity|
|Abstract:||A new series of novel 1-benzoyl-4-(4-aroyl/aroyloxy methyl)-3-methyl-6-oxo-6,7-dihydro-1H-pyrazolo [3,4-b] pyridine-5-carbonitrile have been synthesized from a common intermediate, in good yields. These compounds have been screened for their antibacterial and antifungal activity against different pathogenic strains of bacteria and fungi. The minimum inhibitory concentration (MBC) and minimum fungicidal concentration (MFC) have been determined for the test compounds as well as for reference standards. Compounds 3c, 3f, 3h, 3i, 3n, 3o, 3p have shown good antibacterial activity where as compounds 3b, 3e, 3g, 3i, 3p have displayed better antifungal activity.|
|Appears in Collections:||IJC-B Vol.58B(12) December 2019]|
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|IJCB 58B(12) 1407-1412.pdf||109.18 kB||Adobe PDF||View/Open|
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