Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/52677
Title: One-pot two-step facile synthesis of new 6,7-dihydro-1H—pyrazolo [3,4-b] pyridine-5- carbonitrile hybrids as antimicrobial agents
Authors: Tiwari, Shailendra
Ahmad, Akeel
Keywords: Substituted aroyl/aroyloxymethyl;Schiff base;Pyrazolin;Pyridine;Carbonitrile;Antimicrobial;Antibacterial activity;Antifungal activity
Issue Date: Dec-2019
Publisher: NISCAIR-CSIR, India
Abstract: A new series of novel 1-benzoyl-4-(4-aroyl/aroyloxy methyl)-3-methyl-6-oxo-6,7-dihydro-1H-pyrazolo [3,4-b] pyridine-5-carbonitrile have been synthesized from a common intermediate, in good yields. These compounds have been screened for their antibacterial and antifungal activity against different pathogenic strains of bacteria and fungi. The minimum inhibitory concentration (MBC) and minimum fungicidal concentration (MFC) have been determined for the test compounds as well as for reference standards. Compounds 3c, 3f, 3h, 3i, 3n, 3o, 3p have shown good antibacterial activity where as compounds 3b, 3e, 3g, 3i, 3p have displayed better antifungal activity.
Page(s): 1407-1412
URI: http://nopr.niscair.res.in/handle/123456789/52677
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.58B(12) December 2019]

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