NISCAIR Online Periodicals Repository

NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR)  >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.45 [2007] >
IJEB Vol.45(06) [June 2007] >


Title: Dendritic cells and antigen trapping technology — A revolution in vaccine/immunotherapy strategy
Authors: Pal, Chiranjib
Ganguly, Dipyaman
Paul, Kausik
Pal, Srijib
Keywords: Cancer
Dendritic cell (DC)
Infectious diseases
Immunotherapy
Viral Diseases
Vaccine
Issue Date: Jun-2007
Publisher: CSIR
Abstract: Vaccines based on dendritic cells—the immune system’s key responders to foreign invaders— grabbed the spotlight of this decade. Scientists have devised a dozen different ways to make dendritic cell vaccines. They have linked dendritic cells with all kinds of antigens, including peptides derived from gene mutations, tumor/pathogen RNA, viral vectors, and with whole pathogen/tumor lysate. And they are adding cytokines such as granulocyte macrophage colony stimulating factor or interleukin 4 during dendritic cell growth or maturation or at the site of vaccination to try to boost response. We are still learning the best way to generate the dendritic cells, load them with the antigen and send them to the right place in the body, and use of the biological stage of development of dendritic cells that is best suited to stimulate a response. In the present review attempts have been made to present a comprehensive synopsis of the history, development and ramifications of evolving knowledge on dendritic cell biology and the prospects for being developed as a rational immunotherapeutic tool. Further clinical studies are warranted.
Page(s): 491-504
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Source:IJEB Vol.45(06) [June 2007]

Files in This Item:

File Description SizeFormat
IJEB 45(6) 491-504.pdf491.27 kBAdobe PDFView/Open
 Current Page Visits: 606 
Recommend this item

 

National Knowledge Resources Consortium |  NISCAIR Website |  Contact us |  Feedback

Disclaimer: NISCAIR assumes no responsibility for the statements and opinions advanced by contributors. The editorial staff in its work of examining papers received for publication is helped, in an honorary capacity, by many distinguished engineers and scientists.

CC License Except where otherwise noted, the Articles on this site are licensed under Creative Commons License: CC Attribution-Noncommercial-No Derivative Works 2.5 India

Copyright © 2012 The Council of Scientific and Industrial Research, New Delhi. All rights reserved.

Powered by DSpace Copyright © 2002-2007 MIT and Hewlett-Packard | Compliant to OAI-PMH V 2.0

Home Page Total Visits: 574008 since 06-Feb-2009  Last updated on 26-Aug-2014Webmaster: nopr@niscair.res.in