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Title: | Biological activities of Ocimum sanctum L. fixed oil—An overview |
Authors: | Singh, Surender Taneja, Manish Majumdar, Dipak K |
Keywords: | Antiinflammatory;Analgesic;Dual-inhibitor;Antiulcer;Anticoagulant;Antioxidant;![]() |
Issue Date: | May-2007 |
Publisher: | CSIR |
Abstract: | Seeds of Ocimum sanctum L. (Labiatae; popularly known as ‘Tulsi’ in Hindi and ‘Holy Basil’ in English) contain a pale yellow colored fixed oil. The oil possesses antiinflammatory activity due to dual inhibition of arachidonate metabolism supplemented by antihistaminic activity. The antiinflammatory activity is not dependent on the pituitary adrenal axis. The oil possesses antipyretic activity due to prostaglandin inhibition and peripherally acting analgesic activity. The oil has been found to be effective against formaldehyde or adjuvant induced arthritis and turpentine oil induced joint edema in animals. Lipoxygenase inhibitory histamine antagonistic and antisecretory activities of the oil contribute towards antiulcer activity. The oil can inhibit enhancement of vascular capillary permeability and leucocyte migration following inflammatory stimulus. The LD50 of the oil is 42.5 ml/kg and long-term use of oil at 3 ml/kg dose does not produce any untoward effects in rats. The oil contains ![]() |
Page(s): | 403-412 |
URI: | http://hdl.handle.net/123456789/5266 |
ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
Appears in Collections: | IJEB Vol.45(05) [May 2007] |
Files in This Item:
File | Description | Size | Format | |
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IJEB 45(5) 403-412.pdf | 226.56 kB | Adobe PDF | View/Open |
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