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IJEB Vol.45(04) [April 2007] >


Title: Protective effect of ascorbic acid against oxidative stress induced by inorganic arsenic in liver and kidney of rat
Authors: Sohini
Rana, S V S
Keywords: Arsenic
Ascorbic acid
Kidney
Liver
Oxidative stress
Issue Date: Apr-2007
Publisher: CSIR
Abstract: Ascorbic acid treatment in arsenic trioxide treated rats increased arsenic excretion, inhibited lipid peroxidation, improved GSH status, regulated GSSG turnover and also restored glutathione-S-transferases activity in liver and kidney. Suitable mechanisms leading to ascorbic acid protection have been discussed. Upregulation of GSH dependent enzymes was found to be necessary for a protective effect. Protection is finally attributed to higher GSH levels observed in the liver and kidney of ascorbic acid and inorganic arsenic treated rats. It is also concluded that ascorbic acid protection is influenced by gender dependent factors. Arsenic poisoning is a global problem now. Gender differences need to be considered while applying therapeutic measures.
Page(s): 371-375
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Source:IJEB Vol.45(04) [April 2007]

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