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Research Journals >
Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.45 [2007] >
IJEB Vol.45(05) [May 2007] >
| Title: | Inhibition of selenium dependent glutathione peroxidase and superoxide dismutase in rats by diethyldithiocarbamate: Effect of pre-administration of  -tocopherol |
| Authors: | Prabhu, H Ramachandra
Nandini, M |
| Keywords: | Diethyldithiocarbamate
Selenium dependent glutathione peroxidase
Superoxide dismutase
-tocopherol |
| Issue Date: | May-2007 |
| Publisher: | CSIR |
| Abstract: | Rats pre-administered with -tocopherol (10 mgs/day) for 7 days afforded a significant protection at the tissue level against the lowering of superoxide dismutase and glutathione peroxidase, especially the selenium-dependent glutathione peroxidase. The protective action of -tocopherol in the diethyldithiocarbamate treated rats may be attributed to its antioxidant/free radical scavenging action. It is concluded that selenium-dependent glutathione peroxidase and -tocopherol act in a complementary fashion to block free radical formation. |
| Page(s): | 465-468 |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.45(05) [May 2007]
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