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IJEB Vol.45(05) [May 2007] >


Title: Inhibition of selenium dependent glutathione peroxidase and superoxide dismutase in rats by diethyldithiocarbamate: Effect of pre-administration of -tocopherol
Authors: Prabhu, H Ramachandra
Nandini, M
Keywords: Diethyldithiocarbamate
Selenium dependent glutathione peroxidase
Superoxide dismutase
-tocopherol
Issue Date: May-2007
Publisher: CSIR
Abstract: Rats pre-administered with -tocopherol (10 mgs/day) for 7 days afforded a significant protection at the tissue level against the lowering of superoxide dismutase and glutathione peroxidase, especially the selenium-dependent glutathione peroxidase. The protective action of -tocopherol in the diethyldithiocarbamate treated rats may be attributed to its antioxidant/free radical scavenging action. It is concluded that selenium-dependent glutathione peroxidase and -tocopherol act in a complementary fashion to block free radical formation.
Page(s): 465-468
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Source:IJEB Vol.45(05) [May 2007]

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