Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/5228
Title: Hemodynamic effects of red blood cell aggregation
Authors: Baskurt, Oguz K
Meiselman, Herbert J
Keywords: Hemodynamic mechanism
Red blood cell aggregation
Issue Date: Jan-2007
Publisher: CSIR
Abstract: The influence of red blood cell (RBC) aggregation on blood flow <i style="">in vivo</i> has been under debate since early 1900’s, yet a full understanding has still has not been reached. Enhanced RBC aggregation is well known to increase blood viscosity measured in rotational viscometers. However, it has been demonstrated that RBC aggregation may decrease flow resistance in cylindrical tubes, due to the formation of a cell-poor zone near the tube wall which results from the enhanced central accumulation of RBC. There is also extensive discussion regarding the effects of RBC aggregation on <i style="">in vivo</i> blood flow resistance. Several groups have reported increased microcirculatory flow resistance with enhanced RBC aggregation in experiments that utilized intravital microscopy. Alternatively, whole organ studies revealed that flow resistance may be significantly decreased if RBC aggregation is enhanced. Recently, new techniques have been developed to achieve well-controlled, graded alterations in RBC aggregation without influencing suspending phase properties. Studies using this technique revealed that the effects of RBC aggregation are determined by the degree of aggregation changes, and that this relationship can be explained by different hemodynamic mechanisms.
Description: 25-31
URI: http://hdl.handle.net/123456789/5228
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.45(01) [January 2007]

Files in This Item:
File Description SizeFormat 
IJEB 45(1) 25-31.pdf60.25 kBAdobe PDFView/Open


Items in NOPR are protected by copyright, with all rights reserved, unless otherwise indicated.