NISCAIR Online Periodicals Repository

Research Journals >
Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.48B [2009] >
IJC-B Vol.48B(07) [July 2009] >

Title: Synthesis and pharmacological studies of some phthalimidoxy substituted spiro-thiazolidinone derivatives of isatin
Authors: Bhambi, Dinesh
Sharma, Chirag
Sharma, Shweta
Salvi, Vijay Kumar
Talesara, G L
Keywords: Pyrazoline
Issue Date: Jul-2009
Publisher: CSIR
Abstract: Novel spiro-isatin-thiazolidino-pyrazoline compounds containing alkoxyphthalimide moiety have been synthesized through a four step pathway starting from chalcone 1a-e. Cyclization of these with hydrazine hydrate in absolute ethanol have yielded 1-acetyl-3-(4-aminophenyl)-5-(4-substituted phenyl)-2-pyrazoline 2a-e. Acid catalyzed condensation of 2a-e with isatin 3 has yielded 3-[4-{1-acetyl-5-(4-substituted phenyl)-2-pyrazoline-3-yl}phenylimino]indole-2-one 4a-e. These Schiff bases on reaction with mercaptoacetic acid in presence of anhydrous ZnCl2 gave their corresponding spiro-thiazolidinone derivatives 5a-e. Subsequent treatment with bromoethoxyphthalimide yielded titled compounds 3'-{4-(1-acetyl-5-(4-substituted phenyl)-2-pyrazoline-3-yl)phenyl}-1-N-ethoxyphthalimido-4'H-spiro[indole-3,2'-[1,3]thiazolidene]-2,4'-1H-dione 6a-e.
Page(s): 1006-1012
ISSN: 0975-0983 (Online); 0376-4699 (Print)
Source:IJC-B Vol.48B(07) [July 2009]

Files in This Item:

File Description SizeFormat
IJCB 48B(7) 1006-1012.pdf128.62 kBAdobe PDFView/Open
 Current Page Visits: 30 
Recommend this item


Online Submission of Articles |  NISCAIR Website |  National Knowledge Resources Consortium |  Contact us |  Feedback

Disclaimer: NISCAIR assumes no responsibility for the statements and opinions advanced by contributors. The editorial staff in its work of examining papers received for publication is helped, in an honorary capacity, by many distinguished engineers and scientists.

CC License Except where otherwise noted, the Articles on this site are licensed under Creative Commons License: CC Attribution-Noncommercial-No Derivative Works 2.5 India

Copyright © 2015 The Council of Scientific and Industrial Research, New Delhi. All rights reserved.

Powered by DSpace Copyright © 2002-2007 MIT and Hewlett-Packard | Compliant to OAI-PMH V 2.0

Home Page Total Visits: 168617 since 01-Sep-2015  Last updated on 29-Jun-2016Webmaster: