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Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.48B [2009] >
IJC-B Vol.48B(07) [July 2009] >
| Title: | Synthesis and pharmacological studies of some phthalimidoxy substituted spiro-thiazolidinone derivatives of isatin |
| Authors: | Bhambi, Dinesh
Sharma, Chirag
Sharma, Shweta
Salvi, Vijay Kumar
Talesara, G L |
| Keywords: | Pyrazoline
isatin
spiro-thiazolidinone
bromoethoxyphthalimide |
| Issue Date: | Jul-2009 |
| Publisher: | CSIR |
| Abstract: | Novel spiro-isatin-thiazolidino-pyrazoline compounds containing alkoxyphthalimide moiety have been synthesized through a four step pathway starting from chalcone 1a-e. Cyclization of these with hydrazine hydrate in absolute ethanol have yielded 1-acetyl-3-(4-aminophenyl)-5-(4-substituted phenyl)-2-pyrazoline 2a-e. Acid catalyzed condensation of 2a-e with isatin 3 has yielded 3-[4-{1-acetyl-5-(4-substituted phenyl)-2-pyrazoline-3-yl}phenylimino]indole-2-one 4a-e. These Schiff bases on reaction with mercaptoacetic acid in presence of anhydrous ZnCl2 gave their corresponding spiro-thiazolidinone derivatives 5a-e. Subsequent treatment with bromoethoxyphthalimide yielded titled compounds 3'-{4-(1-acetyl-5-(4-substituted phenyl)-2-pyrazoline-3-yl)phenyl}-1-N-ethoxyphthalimido-4'H-spiro[indole-3,2'-[1,3]thiazolidene]-2,4'-1H-dione 6a-e. |
| Page(s): | 1006-1012 |
| ISSN: | 0975-0983 (Online); 0376-4699 (Print) |
| Source: | IJC-B Vol.48B(07) [July 2009]
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