Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/5200
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dc.contributor.authorShagufta-
dc.contributor.authorSingh, Ritesh-
dc.contributor.authorPanda, Gautam-
dc.date.accessioned2009-07-13T11:00:50Z-
dc.date.available2009-07-13T11:00:50Z-
dc.date.issued2009-07-
dc.identifier.issn0975-0983 (Online); 0376-4699 (Print)-
dc.identifier.urihttp://hdl.handle.net/123456789/5200-
dc.description989-995en_US
dc.description.abstractNew prototype of natural steroid amino acid hybrid containing nine membered D-ring in the steroid skeleton has been synthesized from commercially available estrone using standard synthetic organic transformations. NaIO4 cleavage of the D-ring of the benzylated estriol furnishes the D-seco diol 8, which after a series of organic reactions (protection of the hydroxyl group, oxidation, reductive amination, deprotection and the Yamaguchi cross coupling) gives the coveted steroid-amino acid hybrids. The methodology can be extended for combinatorial synthesis of new and interesting steroid amino acid hybrids.en_US
dc.language.isoen_USen_US
dc.publisherCSIRen_US
dc.sourceIJC-B Vol.48B(07) [July 2009]en_US
dc.subjectSteroiden_US
dc.subjectamino acidsen_US
dc.subjecthybriden_US
dc.subjectYamaguchi couplingen_US
dc.subjectmacrolactonizationen_US
dc.titleSynthetic studies towards steroid-amino acid hybridsen_US
dc.typeArticleen_US
Appears in Collections:IJC-B Vol.48B(07) [July 2009]

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