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Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.48B [2009] >
IJC-B Vol.48B(07) [July 2009] >
| Title: | Synthetic studies towards steroid-amino acid hybrids |
| Authors: | Shagufta
Singh, Ritesh
Panda, Gautam |
| Keywords: | Steroid
amino acids
hybrid
Yamaguchi coupling
macrolactonization |
| Issue Date: | Jul-2009 |
| Publisher: | CSIR |
| Abstract: | New prototype of natural steroid amino acid hybrid containing nine membered D-ring in the steroid skeleton has been synthesized from commercially available estrone using standard synthetic organic transformations. NaIO4 cleavage of the D-ring of the benzylated estriol furnishes the D-seco diol 8, which after a series of organic reactions (protection of the hydroxyl group, oxidation, reductive amination, deprotection and the Yamaguchi cross coupling) gives the coveted steroid-amino acid hybrids. The methodology can be extended for combinatorial synthesis of new and interesting steroid amino acid hybrids. |
| Page(s): | 989-995 |
| ISSN: | 0975-0983 (Online); 0376-4699 (Print) |
| Source: | IJC-B Vol.48B(07) [July 2009]
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