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Title: Synthetic studies towards steroid-amino acid hybrids
Authors: Shagufta
Singh, Ritesh
Panda, Gautam
Keywords: Steroid;amino acids;hybrid;Yamaguchi coupling;macrolactonization
Issue Date: Jul-2009
Publisher: CSIR
Abstract: New prototype of natural steroid amino acid hybrid containing nine membered D-ring in the steroid skeleton has been synthesized from commercially available estrone using standard synthetic organic transformations. NaIO4 cleavage of the D-ring of the benzylated estriol furnishes the D-seco diol 8, which after a series of organic reactions (protection of the hydroxyl group, oxidation, reductive amination, deprotection and the Yamaguchi cross coupling) gives the coveted steroid-amino acid hybrids. The methodology can be extended for combinatorial synthesis of new and interesting steroid amino acid hybrids.
Page(s): 989-995
ISSN: 0975-0983 (Online); 0376-4699 (Print)
Appears in Collections:IJC-B Vol.48B(07) [July 2009]

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