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Title: HOAt.DCHA as co-coupling agent in the synthesis of peptides employing Fmoc-amino acid chlorides as coupling agents: Application to the synthesis of β-casomorphin
Authors: Sureshbabu, Vommina V
Chennakrishnareddy, Gundala
Keywords: Amino acid chlorides;1-hydroxy-7-azabenzotriazole;co-coupling agent;non Schotten-Baumann condition;racemization free coupling
Issue Date: Jul-2009
Publisher: CSIR
Abstract: A simple, efficient and racemization free method for the synthesis of peptides employing Fmoc-amino acid chlorides mediated by HOAt.DCHA as a co-coupling agent has been described. This protocol is successfully employed in the synthesis of the pentapeptide H-Pro-Gly-Val-Gly-Val-OH (PGVGV), and β-casomorphin (H-Tyr-Pro-Phe-Pro-Gly-OH) in 85 and 80% yields, respectively.
Page(s): 981-988
ISSN: 0975-0983 (Online); 0376-4699 (Print)
Appears in Collections:IJC-B Vol.48B(07) [July 2009]

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