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Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.48B [2009] >
IJC-B Vol.48B(07) [July 2009] >
| Title: | HOAt.DCHA as co-coupling agent in the synthesis of peptides employing Fmoc-amino acid chlorides as coupling agents: Application to the synthesis of β-casomorphin |
| Authors: | Sureshbabu, Vommina V
Chennakrishnareddy, Gundala |
| Keywords: | Amino acid chlorides
1-hydroxy-7-azabenzotriazole
co-coupling agent
non Schotten-Baumann condition
racemization free coupling |
| Issue Date: | Jul-2009 |
| Publisher: | CSIR |
| Abstract: | A simple, efficient and racemization free method for the synthesis of peptides employing Fmoc-amino acid chlorides mediated by HOAt.DCHA as a co-coupling agent has been described. This protocol is successfully employed in the synthesis of the pentapeptide H-Pro-Gly-Val-Gly-Val-OH (PGVGV), and β-casomorphin (H-Tyr-Pro-Phe-Pro-Gly-OH) in 85 and 80% yields, respectively. |
| Page(s): | 981-988 |
| ISSN: | 0975-0983 (Online); 0376-4699 (Print) |
| Source: | IJC-B Vol.48B(07) [July 2009]
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