NISCAIR Online Periodicals Repository

Research Journals >
Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.48B [2009] >
IJC-B Vol.48B(07) [July 2009] >

Title: HOAt.DCHA as co-coupling agent in the synthesis of peptides employing Fmoc-amino acid chlorides as coupling agents: Application to the synthesis of β-casomorphin
Authors: Sureshbabu, Vommina V
Chennakrishnareddy, Gundala
Keywords: Amino acid chlorides
co-coupling agent
non Schotten-Baumann condition
racemization free coupling
Issue Date: Jul-2009
Publisher: CSIR
Abstract: A simple, efficient and racemization free method for the synthesis of peptides employing Fmoc-amino acid chlorides mediated by HOAt.DCHA as a co-coupling agent has been described. This protocol is successfully employed in the synthesis of the pentapeptide H-Pro-Gly-Val-Gly-Val-OH (PGVGV), and β-casomorphin (H-Tyr-Pro-Phe-Pro-Gly-OH) in 85 and 80% yields, respectively.
Page(s): 981-988
ISSN: 0975-0983 (Online); 0376-4699 (Print)
Source:IJC-B Vol.48B(07) [July 2009]

Files in This Item:

File Description SizeFormat
IJCB 48B(7) 981-988.pdf223.81 kBAdobe PDFView/Open
 Current Page Visits: 82 
Recommend this item


Online Submission of Articles |  NISCAIR Website |  National Knowledge Resources Consortium |  Contact us |  Feedback

Disclaimer: NISCAIR assumes no responsibility for the statements and opinions advanced by contributors. The editorial staff in its work of examining papers received for publication is helped, in an honorary capacity, by many distinguished engineers and scientists.

CC License Except where otherwise noted, the Articles on this site are licensed under Creative Commons License: CC Attribution-Noncommercial-No Derivative Works 2.5 India

Copyright © 2015 The Council of Scientific and Industrial Research, New Delhi. All rights reserved.

Powered by DSpace Copyright © 2002-2007 MIT and Hewlett-Packard | Compliant to OAI-PMH V 2.0

Home Page Total Visits: 167309 since 01-Sep-2015  Last updated on 28-Jun-2016Webmaster: