Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/5161
Title: Charge transfer complexes of chloranil with drugs
Authors: Veeraiah, T
Anjaiah, G
Reddy, P Kista
Keywords: Charge transfer
Chloranil
Drugs
Issue Date: Jul-2005
Publisher: CSIR
Series/Report no.: A 61 K 9/00
Abstract: The study of charge transfer (CT) complexes of chloranil with drugs (Naproxen, Nerolin, Methyl anthranilate, Isoxsuprine and Nylidrin) showed that there is a significant interaction between the acceptor and donors as evidenced by colour changes and absorption spectra. From the position of CT bands, the ionization potentials (IPs) of donors were evaluated using appropriate equations. The donor’s abilities are in the following order: Naproxen > Nerolin > Methyl anthranilate > Isoxsuprine > Nylidrin. Benesi-Hildebrand plots, Job's variation method indicated the formation of 1:1 complex in each case. The stability constants that varied in the same order as IPs are useful in estimation of the concentration of drugs either in pure form or in formulations and give a guide to the estimation of the drugs in industry and pharmacy. Thermodynamic parameters (-ve values of <i style=""><img src='/image/spc_char/delta.gif'>H</i>) suggest that the formation of complex is exothermic. The <i style="">-</i><i style=""><img src='/image/spc_char/delta.gif'>S</i> values indicate a decrease in the degree of freedom of molecules upon complexation, while -<i style=""><img src='/image/spc_char/delta.gif'>G</i> values indicate that complex formation is spontaneous and the values give a relative estimation of interaction between donors and acceptor.
Description: 504-508
URI: http://hdl.handle.net/123456789/5161
ISSN: 0975-1084 (Online); 0022-4456 (Print)
Appears in Collections:JSIR Vol.64(07) [July 2005]

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