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JSIR Vol.64 [2005] >
JSIR Vol.64(04) [April 2005] >
| Title: | Stability and flow behaviour of barium sulphate suspension and the preparation of stable barium sulphate suspension for medical use |
| Authors: | Nag, Ahindra |
| Keywords: | Barium sulphate suspension
Additives
Sodium carboxy methyl cellulose
Trisodium citrate
Viscosity
Rheogram template
Adsorption studies
Stability of suspension and Gastrointestinal tract
X-ray studies |
| Issue Date: | Apr-2005 |
| Publisher: | CSIR |
| IPC Code: | A 61 K 49/00 |
| Abstract: | Stability and flow behaviour of concentrated barium sulphate suspension (BSS) was studied in the presence of sodium carboxy methyl cellulose (NaCMC), bentonite and poly vinyl pyrrolidone (PVP). NaCMC (0.2 %) showed maximum viscosity (50 %), maximum sedimentation volume of BSS and maximum (0.4 %) adsorption of NaCMC by BSS. Bentonite and PVP had no significant effect on sedimentation volume of BSS but increased the viscosity . The radiological studies on the X-ray picture of rabbit using BSS (50 %) and NaCMC (0.2 %) exhibited poor contrast of the stomach region. To increase the stability, suspension was mixed with tri sodium citrate (4 %). The X-ray picture of rabbit showed good contrast of the stomach as well as the small intestine region. |
| Page(s): | 268-272 |
| ISSN: | 0975-1084 (Online); 0022-4456 (Print) |
| Source: | JSIR Vol.64(04) [April 2005]
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