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JSIR Vol.64(04) [April 2005] >


Title: Stability and flow behaviour of barium sulphate suspension and the preparation of stable barium sulphate suspension for medical use
Authors: Nag, Ahindra
Keywords: Barium sulphate suspension
Additives
Sodium carboxy methyl cellulose
Trisodium citrate
Viscosity
Rheogram template
Adsorption studies
Stability of suspension and Gastrointestinal tract
X-ray studies
Issue Date: Apr-2005
Publisher: CSIR
IPC CodeA 61 K 49/00
Abstract: Stability and flow behaviour of concentrated barium sulphate suspension (BSS) was studied in the presence of sodium carboxy methyl cellulose (NaCMC), bentonite and poly vinyl pyrrolidone (PVP). NaCMC (0.2 %) showed maximum viscosity (50 %), maximum sedimentation volume of BSS and maximum (0.4 %) adsorption of NaCMC by BSS. Bentonite and PVP had no significant effect on sedimentation volume of BSS but increased the viscosity . The radiological studies on the X-ray picture of rabbit using BSS (50 %) and NaCMC (0.2 %) exhibited poor contrast of the stomach region. To increase the stability, suspension was mixed with tri sodium citrate (4 %). The X-ray picture of rabbit showed good contrast of the stomach as well as the small intestine region.
Page(s): 268-272
ISSN: 0975-1084 (Online); 0022-4456 (Print)
Source:JSIR Vol.64(04) [April 2005]

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