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Title: Synthesis of dihydro-1,4-thiazine from α-keto spiro-thiazolidine
Authors: Utsukihara, Takamitsu
Matsushita, Masatoshi
Miyamoto, Eri
Murakami, Hikaru
Horiuchi, C Akira
Keywords: 1,4-Thiazine compounds;Spiro-thiazolidine derivatives;Microwave irradiation;Intramolecular reaction
Issue Date: Sep-2019
Publisher: NISCAIR-CSIR, India
Abstract: The reaction of α-bromocycloalkanone with 2-aminoethanthiol leads to the regioselective formation of spirothiazolidin-2-one with the oxo-group migrating to the original position occupied by the halogen atom. The reaction of 1-thia-4-azaspiro[4.5]alkan-6-one with bromine, iodine, copper (II) salts, acid or base gives dihydro-1,4-thiazine derivatives in moderate yields. Moreover, the treatment of the spiro-thiazolidine derivatives on silica gel under microwave gives the 1,4-thiazine compound.
Page(s): 1037-1041
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.58B(09) [September 2019]

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