Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/5043
Title: Antihyperglycemic, antihyperlipidemic and antioxidant effects of Dihar, a polyherbal ayurvedic formulation in streptozotocin induced diabetic rats
Authors: Patel, Snehal S
Shah, Rajendra S
Goyal, Ramesh K
Keywords: Antidiabetic
Antioxidant
Polyherbal formulation
Lipid profile
Oxidative stress
Streptozotocin
Issue Date: Jul-2009
Publisher: CSIR
Abstract: Present investigation was undertaken to evaluate antihyperglycemic, antihyperlipidemic and antioxidant activities of Dihar, a polyherbal formulation containing drugs from eight different herbs viz., <i style="">Syzygium cumini, Momordica charantia, Emblica officinalis, Gymnema sylvestre, Enicostemma littorale, Azadirachta indica, Tinospora cordifolia </i>and<i style=""> Curcuma longa</i> in<i style=""> </i>streptozotocin (STZ, 45mg/kg iv single dose) induced type 1 diabetic rats. STZ produced a significant increase in serum glucose, cholesterol, triglyceride, very low density lipoprotein, low density lipoprotein, creatinine, and urea levels in diabetic rat. Treatment with Dihar (100 mg/kg) for 6 weeks produced decrease in STZ induced serum glucose and lipids levels and increased insulin levels as compared to control. Dihar produced significant decrease in serum creatinine and urea levels in diabetic rats. There was a significant decrease in reduced glutathione, superoxide dismutase, catalase levels and increase in thiobarbituiric acid reactive species levels in the liver of STZ-induced diabetic rats. Administration of Dihar to diabetic rats significantly reduced the levels of lipid paroxidation and increased the activities of antioxidant enzymes. The results suggest Dihar to be beneficial for the treatment of type 1 diabetes
Description: 564-570
URI: http://hdl.handle.net/123456789/5043
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.47(07) [July 2009]

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