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Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.47 [2009] >
IJEB Vol.47(07) [July 2009] >
| Title: | Effect of alpha-tocopherol supplementation on renal oxidative stress and Na+/K+-adenosine triphosphatase in ethanol treated Wistar rats |
| Authors: | Mailankot, Maneesh
Jayalekshmi, H
Chakrabarti, Amit
Alang, Neha
Vasudevan, D M |
| Keywords: | Alpha-tocopherol
Ethanol
Kidney
Oxidative stress
Na+ / K+-ATPase |
| Issue Date: | Jul-2009 |
| Publisher: | CSIR |
| Abstract: | Ethanol intoxication resulted in high extent of lipid peroxidation, and reduction in antioxidant defenses (decreased GSH, GSH/GSSG ratio, and catalase, SOD and GPx activities) and (Na+/K+)-ATPase activity in kidney. Alpha-tocopherol treatment effectively protected kidney from ethanol induced oxidative challenge and improved renal (Na+/K+)-ATPase activity. Ethanol induced oxidative stress in the kidney and decreased (Na+/K+)-ATPase activity could be reversed by treatment with ascorbic acid. |
| Page(s): | 608-610 |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.47(07) [July 2009]
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