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IJEB Vol.47(07) [July 2009] >


Title: Effect of alpha-tocopherol supplementation on renal oxidative stress and Na+/K+-adenosine triphosphatase in ethanol treated Wistar rats
Authors: Mailankot, Maneesh
Jayalekshmi, H
Chakrabarti, Amit
Alang, Neha
Vasudevan, D M
Keywords: Alpha-tocopherol
Ethanol
Kidney
Oxidative stress
Na+ / K+-ATPase
Issue Date: Jul-2009
Publisher: CSIR
Abstract: Ethanol intoxication resulted in high extent of lipid peroxidation, and reduction in antioxidant defenses (decreased GSH, GSH/GSSG ratio, and catalase, SOD and GPx activities) and (Na+/K+)-ATPase activity in kidney. Alpha-tocopherol treatment effectively protected kidney from ethanol induced oxidative challenge and improved renal (Na+/K+)-ATPase activity. Ethanol induced oxidative stress in the kidney and decreased (Na+/K+)-ATPase activity could be reversed by treatment with ascorbic acid.
Page(s): 608-610
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Source:IJEB Vol.47(07) [July 2009]

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