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Title: Anti-inflammatory, immunomodulatory and antinociceptive activity of Terminalia arjuna Roxb bark powder in mice and rats
Authors: Halder, Sumita
Bharal, Nidhi
Mediratta, Pramod K
Kaur, Inderjeet
Sharma, Krishna K
Keywords: Anti-inflammatory
Formalin-induced pain response
Humoral immune response
Tail flick latency test
Terminalia arjuna
Issue Date: Jul-2009
Publisher: CSIR
Abstract: Terminalia arjuna back powder (400 mg/kg,po) significantly reduced formalin-indued paw oedema at 24 h but not carrageenan-induced paw oedema. It significantly increased the anti-SRBC antibody titre in the secondary phase of immune response. The same dose significantly reduced the duration of licks and bites in both phases of formalin-induced pain response and showed significant increase in tail flick latency at higher dose (800mg/kg,po). These effects of T.arjuna were antagonised by pretreatment with naloxone (1mg/kg,ip). In another series of experiments, mice pretreated with morphine for three days in increasing doses (10, 15, 20 mg/kg, ip; twice daily) showed a decreased response in antinociceptive activity of morphine (5 mg/kg, ip). Further, cross tolerance was observed with T.arjuna (800mg/kg, po) in morphine tolerant animals. These findings support the hypothesis that T.arjuna has anti-inflammatory potential against some phlogistic agents along with some immunomodulatory activity and also has antinococeptive action probably mediated via central opioid receptors.
Page(s): 577-583
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Source:IJEB Vol.47(07) [July 2009]

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