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IJEB Vol.47(07) [July 2009] >


Title: Protective potentials of a plant extract (Lycopodium clavatum) on mice chronically fed hepato-carcinogens
Authors: Pathak, Surajit
Banerjee, Antara
Paul, Saili
Khuda-Bukhsh, Anisur Rahman
Keywords: Acid and alkaline phosphatase
Hepatoprotective
Lycopodium clavatum
p-dimethyl aminoazobenzene
Phenobarbital
Issue Date: Jul-2009
Publisher: CSIR
Abstract: Chronic feeding of carcinogens p-dimethylamino azobenzene (initiator) and phenobarbital (promoter) for 90 and 120 days elevated activities of acid and alkaline phosphatases, levels of blood glucose and cortisol and decreased the activities of glutathione reductase, succinate dehydrogenase, and blood cholesterol and hemoglobin contents, and levels of serum estradiol and testosterone in mice. Levels of these biomarkers in both liver and spleen tissues were positively altered along with a significant reduction of tumor incidence in liver of carcinogen intoxicated mice treated with spore extract of Lycopodium clavatum. The results validate the use of this plant extract in complementary and alternative medicines against hepato-toxicity.
Page(s): 602-607
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Source:IJEB Vol.47(07) [July 2009]

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