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|Title:||Bioactive potential of actinobacteria isolated from the gut of marine fishes|
|Keywords:||Actinobacteria;Fish gut;Antimicrobial and antiquorum sensing activity;Agar plug method|
|Abstract:||The study was undertaken to explore the gut-associated actinobacteria from two marine fish with special reference to antimicrobial and anti-quorum sensing activity. A total of 40 actinobacterial strains were isolated from fish gut samples using starch casein agar and Kuster’s agar medium. About 14 morphologically different strains recovered from Rastrelliger kanagurta (Indian mackerel) and Panna microdon (Panna croaker) were screened for the antimicrobial activity against Staphylococcus aureus MTCC96, Escherichia coli MTCC739, Salmonella enterica, Candida albicans, and quorum sensing inhibition (QSI) against Chromobacterium violaceum and Serratia marcescens. The actinobacterial strain IM20 from R. kanagurta showed both antimicrobial and QSI activity, whereas the strains PCA1 and PCA4 from P. microdon showed only antimicrobial activity. Strain IM20, which showed wide range of activity, was selected as the potential strain for further studies. Thus, the findings suggested that the fish-associated actinobacteria is a promising source for antimicrobial compounds for developing novel therapeutic drugs.|
|ISSN:||0975-1033 (Online); 0379-5136 (Print)|
|Appears in Collections:||IJMS Vol.48(08) [August 2019]|
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