NISCAIR Online Periodicals Repository

Research Journals >
Journal of Scientific and Industrial Research (JSIR) >
JSIR Vol.65 [2006] >
JSIR Vol.65(10) [October 2006] >

Title: Design and evaluation of bilayer floating tablets of cefuroxime axetil for bimodal release
Authors: Dhumal, Ravindra S
Rajmane, Samitkumar T
Dhumal, Sanjay T
Pawar, Atmaram P
Keywords: Bimodal drug delivery
Cefuroxime axetil
Floating drug delivery system
Issue Date: Oct-2006
Publisher: CSIR
IPC CodeA61K9/00
Abstract: Study aims to design a gastroretentive delivery system for bimodal release of cefuroxime axetil (CA). CA has site-specific absorption from upper gastrointestinal tract and in intestine it undergoes hydrolysis to cefuroxime having poor absorption. Unabsorbed drug causes high concentration of antibiotic entering colon and contributes to the side effects like colitis. Therefore, a gastro-retentive dosage form is required to ensure controlled drug delivery within drug-absorbable regions. Bilayer tablet, each layer containing half the dose of drug was formulated with one immediate release layer (IRL) and another floating matrix layer (FML). The FML showed good floating properties with buoyancy lag time of 12-35 min and floating time of 8-24 h. Thus, bimodal drug release comprising of immediate release for quick onset of action followed by controlled release minimizing the concentration of unabsorbed drug entering colon was achieved. No change in amorphous nature of drug during processing was observed, which was confirmed by differential scanning colorimeter and X-ray diffractometer. The -sintigraphy confirmed the gastric residence of tablets in human volunteers.
Page(s): 812-816
ISSN: 0975-1084 (Online); 0022-4456 (Print)
Source:JSIR Vol.65(10) [October 2006]

Files in This Item:

File Description SizeFormat
JSIR 65(10) 812-816.pdf139.97 kBAdobe PDFView/Open
 Current Page Visits: 245 
Recommend this item


Online Submission of Articles |  NISCAIR Website |  National Knowledge Resources Consortium |  Contact us |  Feedback

Disclaimer: NISCAIR assumes no responsibility for the statements and opinions advanced by contributors. The editorial staff in its work of examining papers received for publication is helped, in an honorary capacity, by many distinguished engineers and scientists.

CC License Except where otherwise noted, the Articles on this site are licensed under Creative Commons License: CC Attribution-Noncommercial-No Derivative Works 2.5 India

Copyright © 2015 The Council of Scientific and Industrial Research, New Delhi. All rights reserved.

Powered by DSpace Copyright © 2002-2007 MIT and Hewlett-Packard | Compliant to OAI-PMH V 2.0

Home Page Total Visits: 170831 since 01-Sep-2015  Last updated on 30-Jun-2016Webmaster: