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Title: Macrotyloma uniflorum (Lam.) Verdc. improves glucose metabolism and proinflammatory parameters in high fructose fed rats
Authors: Ramanathan, Veerappan
Raj, Dominic Amal
Thekkumalai, Malarvili
Keywords: Adiponectin;Fructose diet;Glucocorticoid;Horsegram;Insulin resistance;Leptin;Mitochondrial enzymes
Issue Date: Aug-2019
Publisher: NISCAIR-CSIR, India
Abstract: Diabetes mellitus (DM) is the most common chronic metabolic disease and its complications constitute major health problems in heart, kidneys, eyes and nerves. The high fructose fed diet (HFFD) induces insulin resistance (IR), hyperinsulinaemia, hyperglycemia, alterations in lipid metabolism, and oxidative stress which plays a vital role in pathology associated with insulin resistance. Here, we explored the possible role of common pulse, horsegram (Macrotyloma uniflorum) as a therapeutic adjunct in a metabolic state of insulin resistance. Male adult Wistar strain albino rats (160-180 g) were divided into four groups of six rats in each. It is observed that the levels of Corticosterone (GC) and protein-bound sugars were higher and activities of liver mitochondrial enzymes were altered in HFFD rats, as compared to control animals. With the administered with M. uniflorum as adjunct in treatment of IR treatment which are functioned by increased GC in liver and adipose tissue and by stimulated liver mitochondrial enzymes activities and IR with reduce fructose.
Page(s): 594-601
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.57(08) [August 2019]

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