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Title: Methylenetetrahydrofolate reductase gene (C677T and A1298C) polymorphisms and hyperhomocysteinemia as risk factors for Myocardial Infarction
Authors: Eissa, Adil A
Rasool, Chiman Saleem
Mustafa, Majeed Hussein
Keywords: Hyperhomocysteinemia;Kurds;Methylenetetrahydrofolate reductase;Myocardial infarction
Issue Date: Aug-2019
Publisher: NISCAIR-CSIR, India
Abstract: Conflicting data concerning the association between methylenetetrahydrofolate reductase gene MTHFR (C677T and A1298C) polymorphisms with or without hyperhomocysteinemia and myocardial infarction exists and data from developing countries is limited thus, a current study initiated to study whether any association exist between the above polymorphisms and myocardial infarction among Kurdish patients from Duhok province/Iraq.
A case-control study was performed in Azadi teaching hospital/Duhok/Iraq and included 75 patients with acute myocardial infarction and 75 age and sex-matched normal controls. All the patients and controls had their methylenetetrahydrofolate reductase gene analyzed for C677T and A1298C polymorphism using polymerase chain reaction/restriction fragment length polymorphism technique as well as their homocysteine level.
Page(s): 321-324
ISSN: 0975-0959 (Online); 0301-1208 (Print)
Appears in Collections:IJBB Vol.56(4) [August 2019]

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