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Title: The in vivo evaluation of antinociceptive and antipyretic activities of Marrubium deserti De Noé infusion extract
Authors: Somia, Saad
Saida, Ouafi
Keywords: M. deserti;Infusion;Phytochemical screening;Acute toxicity;Antinociceptive;Antipyretic
Issue Date: Jul-2019
Publisher: NISCAIR-CSIR, India
IPC Code: Int. Cl.19: A01G 13/00, A47G 19/16, A61K 36/00, A62D 101/08, A61K 31/485, A61P 29/00
Abstract: The aim of this study was to evaluate the in vivo antinociceptive and antipyretic activities of Marrubium deserti De Noé infusion extract. Antinociceptive effect was evaluated by acetic acid induced writhing response, formalin-induced paw licking and the hot plat method in mice, while antipyretic activity was tested by brewer’s yeast induced pyrexia in rats. In each test, we examined the doses of 250, 500 and 1000 mg/kg body weight (bw) of the extract. The infusion extract produced dose-dependent antinociceptive effect against chemically and thermally induced nociceptive pain stimuli in mice. In acetic acid induced writhing test, the inhibition percentage of writhing response was 49.12% at 1000 mg/kg bw (p<0.001). This extract also significantly (p<0.001) inhibited the licking response of the formalin test at 1000 mg/kg bw in both the early phase (64.39%) and the late phase (70.75%). In the hot plate method, the infusion extract significantly (p<0.001) increased the reaction time to heat sensation to 58.21% at 1000 mg/kg bw Moreover, the extract possessed an excellent (p<0.001) antipyretic effect and even better than the reference drug. These findings indicate that M. deserti De Noé infusion extract possesses antinociceptive and antipyretic activities which could be due to the presence of bioactive compounds in this plant.
Page(s): 468-476
ISSN: 0975-1068 (Online); 0972-5938 (Print)
Appears in Collections:IJTK Vol.18(3) [July 2019]

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