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Title: Total phenolic and flavonoid content, antioxidant effects and antidiarrheal activity of balacaturbhadrika churna – an Ayurvedic preparation
Authors: Pratap, Rahul
Ram, HN Aswatha
Chandrashekar, KS
Pai, Vasudev
Khan, Saleemulla
Kamath, Venkatesh
Keywords: ABTS;Antidiarrheal;Antioxidant;Balacaturbhadrika churna;DPPH;Flavonoid;Phenolic
Issue Date: Jul-2019
Publisher: NISCAIR-CSIR, India
IPC Code: Int. Cl.19: A61K 39/395, A61K 9/00, A61P 17/18, A61K 36/00, A61K 8/97, C12G 3/05, A61K 31/05
Abstract: Balacaturbhadrika churna (BC) is an important pediatric preparation in Ayurveda. It is used to treat various diseases of gastro-intestinal tract particularly diarrhea in children. Free radicals cause oxidative damage in the intestine and are correlated with its diseases. In the current study, total phenolic and flavonoid contents of BC extracts were determined and their antioxidant evaluation in various in vitro models was carried out. Procedures mentioned in The Ayurvedic Formulary of India were followed to prepare in-house BC; alcoholic (BCAL) and aqueous (BCAQ) extracts were prepared and tested by standard procedures. BCAL was tested for antidiarrheal activity in castor oil induced model. The ethanolic extract showed better antioxidant activity in many of the models as compared to aqueous extract. The present study showed substantial amounts of flavonoids and phenolics in churna extracts. BCAL showed significant antidiarrheal activity against the tested model. The potential antioxidant and antidiarrheal activities displayed by Balacaturbhadrika churna extracts could be attributed to these contents.
Page(s): 485-492
ISSN: 0975-1068 (Online); 0972-5938 (Print)
Appears in Collections:IJTK Vol.18(3) [July 2019]

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