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dc.contributor.authorChen, Yunhui-
dc.contributor.authorTang, Shiyun-
dc.contributor.authorLiu, Xinglong-
dc.contributor.authorZhang, Xiaodan-
dc.contributor.authorWan, Peng-
dc.contributor.authorHuang, Wei-
dc.contributor.authorTang, Songqi-
dc.identifier.issn0975-1068 (Online); 0972-5938 (Print)-
dc.description.abstractXuefu Zhuyu Tang (XFZY), a famous formula in traditional Chinese medicine, has been demonstrated to show good therapeutic effects on diseases caused by blood stasis syndrome. Two of its eleven herbs, Radix Platycodonis and Radix Cyathulae, have been considered as Shi ingredients in the hierarchy of traditional formula compatibility and proven possessing synergistic properties that strengthen the formula's potency of activating blood circulation and resolving blood stagnation. However, its mechanism is still not clearly elucidated. In our previous study, we observed their effects on paeoniflorin pharmacokinetics of XFZY in rats. In this study, we continued by detecting and comparing their effect on the tissue distribution of paeoniflorin after oral administration of XFZY and its three variants (XFZY without Radix Platycodonis or/and Radix Cyathulae) in blood-stasis mice via HPLC assay. The results indicated that combining usage of Radix Platycodonis and Radix Cyathula increased the distribution of paeoniflorin in the lung and kidney and introduced the paeoniflorin into the liver, spleen and heart. It might explain their synergistic properties that strengthen the formula's effect of invigorating blood and dissolving stasis and provide experimental evidence to understand the pharmacological effects of Shi herbs in the hierarchy of traditional formula compatibility.en_US
dc.publisherNISCAIR-CSIR, Indiaen_US
dc.relation.ispartofseriesInt. Cl.19: A61K 35/16, A61K 36/65, A01G 13/00, A01G 13/00, A61K 36/00, A61K 35/35, A61K 36/00, A61K 36/00en_US
dc.rights CC Attribution-Noncommercial-No Derivative Works 2.5 Indiaen_US
dc.sourceIJTK Vol.18(3) [July 2019]en_US
dc.subjectBlood stasis syndromeen_US
dc.subjectRadix cyathulaeen_US
dc.subjectRadix platycodonisen_US
dc.subjectShi ingredienten_US
dc.subjectTissue distributionen_US
dc.subjectTraditional formula compatibilityen_US
dc.subjectXuefu Zhuyu Tangen_US
dc.titleEffect of Radix Platycodonis and Radix Cyathulae in Xuefu Zhuyu Tang on tissue distribution of paeoniflorin in blood-stasis mice by HPLC: Experimental evidence on Shi ingredients in traditional formula compatibilityen_US
Appears in Collections:IJTK Vol.18(3) [July 2019]

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