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Title: Effect of Radix Platycodonis and Radix Cyathulae in Xuefu Zhuyu Tang on tissue distribution of paeoniflorin in blood-stasis mice by HPLC: Experimental evidence on Shi ingredients in traditional formula compatibility
Authors: Chen, Yunhui
Tang, Shiyun
Liu, Xinglong
Zhang, Xiaodan
Wan, Peng
Huang, Wei
Tang, Songqi
Keywords: Blood stasis syndrome;Paeoniflorin;Radix cyathulae;Radix platycodonis;Shi ingredient;Tissue distribution;Traditional formula compatibility;Xuefu Zhuyu Tang
Issue Date: Jul-2019
Publisher: NISCAIR-CSIR, India
IPC Code: Int. Cl.19: A61K 35/16, A61K 36/65, A01G 13/00, A01G 13/00, A61K 36/00, A61K 35/35, A61K 36/00, A61K 36/00
Abstract: Xuefu Zhuyu Tang (XFZY), a famous formula in traditional Chinese medicine, has been demonstrated to show good therapeutic effects on diseases caused by blood stasis syndrome. Two of its eleven herbs, Radix Platycodonis and Radix Cyathulae, have been considered as Shi ingredients in the hierarchy of traditional formula compatibility and proven possessing synergistic properties that strengthen the formula's potency of activating blood circulation and resolving blood stagnation. However, its mechanism is still not clearly elucidated. In our previous study, we observed their effects on paeoniflorin pharmacokinetics of XFZY in rats. In this study, we continued by detecting and comparing their effect on the tissue distribution of paeoniflorin after oral administration of XFZY and its three variants (XFZY without Radix Platycodonis or/and Radix Cyathulae) in blood-stasis mice via HPLC assay. The results indicated that combining usage of Radix Platycodonis and Radix Cyathula increased the distribution of paeoniflorin in the lung and kidney and introduced the paeoniflorin into the liver, spleen and heart. It might explain their synergistic properties that strengthen the formula's effect of invigorating blood and dissolving stasis and provide experimental evidence to understand the pharmacological effects of Shi herbs in the hierarchy of traditional formula compatibility.
Page(s): 516-524
ISSN: 0975-1068 (Online); 0972-5938 (Print)
Appears in Collections:IJTK Vol.18(3) [July 2019]

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