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Title: One - pot Reformatsky-Imine addition reaction-leading to the synthesis of structurally diverse β-lactams
Authors: Rajput, Jaspreet
Singh, Baldev
Singal, Kewal Krishan
Keywords: Reformatsky reaction;β-lactams;Imines;⍺-bromoethylacetate;⍺-methylcinnamaldehyde
Issue Date: Apr-2007
Publisher: CSIR
IPC Code: Int. Cl.⁸ C07D
Abstract: The Reformatsky-imine addition reaction of ⍺-bromoethylacetate with aldimines derived from 3,4-methylenedioxy benzaldehyde and ⍺-methylcinnamaldehyde has provided an efficient and practical access to structurally diverse β-lactams. All the new β-lactams have been identified as 1,4-diaryl-2-azetidinones through their detailed spectral studies. Further it also reveals that the styryl bond of ⍺-methylcinnamylideneanilines does not participate in the reaction and gives β-lactams contrary to their analogues cinnamylideneanilines15 and o-nitrocinnamylideneanilines16 which gave δ-lactams.
Page(s): 643-648
ISSN: 0376-4699
Appears in Collections:IJC-B Vol.46B(04) [April 2007]

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