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Title: | One - pot Reformatsky-Imine addition reaction-leading to the synthesis of structurally diverse β-lactams |
Authors: | Rajput, Jaspreet Singh, Baldev Singal, Kewal Krishan |
Keywords: | Reformatsky reaction;β-lactams;Imines;⍺-bromoethylacetate;⍺-methylcinnamaldehyde |
Issue Date: | Apr-2007 |
Publisher: | CSIR |
IPC Code: | Int. Cl.⁸ C07D |
Abstract: | The Reformatsky-imine addition reaction of ⍺-bromoethylacetate with aldimines derived from 3,4-methylenedioxy benzaldehyde and ⍺-methylcinnamaldehyde has provided an efficient and practical access to structurally diverse β-lactams. All the new β-lactams have been identified as 1,4-diaryl-2-azetidinones through their detailed spectral studies. Further it also reveals that the styryl bond of ⍺-methylcinnamylideneanilines does not participate in the reaction and gives β-lactams contrary to their analogues cinnamylideneanilines15 and o-nitrocinnamylideneanilines16 which gave δ-lactams. |
Page(s): | 643-648 |
URI: | http://hdl.handle.net/123456789/493 |
ISSN: | 0376-4699 |
Appears in Collections: | IJC-B Vol.46B(04) [April 2007] |
Files in This Item:
File | Description | Size | Format | |
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IJCB 46B(4) (2007) 643-648.pdf | 86.85 kB | Adobe PDF | View/Open |
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