|
NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR) >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.46B [2007] >
IJC-B Vol.46B(04) [April 2007] >
| Title: | One - pot Reformatsky-Imine addition reaction-leading to the synthesis of structurally diverse β-lactams |
| Authors: | Rajput, Jaspreet
Singh, Baldev
Singal, Kewal Krishan |
| Keywords: | Reformatsky reaction
β-lactams
Imines
⍺-bromoethylacetate
⍺-methylcinnamaldehyde |
| Issue Date: | Apr-2007 |
| Publisher: | CSIR |
| IPC Code: | Int. Cl.⁸ C07D |
| Abstract: | The Reformatsky-imine addition reaction of ⍺-bromoethylacetate with aldimines derived from 3,4-methylenedioxy benzaldehyde and ⍺-methylcinnamaldehyde has provided an efficient and practical access to structurally diverse β-lactams. All the new β-lactams have been identified as 1,4-diaryl-2-azetidinones through their detailed spectral studies. Further it also reveals that the styryl bond of ⍺-methylcinnamylideneanilines does not participate in the reaction and gives β-lactams contrary to their analogues cinnamylideneanilines15 and o-nitrocinnamylideneanilines16 which gave δ-lactams. |
| Page(s): | 643-648 |
| ISSN: | 0376-4699 |
| Source: | IJC-B Vol.46B(04) [April 2007]
|
|
