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Title: Synthesis, characterization and antimicrobial activity of some coumarin fused heterocycles
Authors: Shirahatti, Arunkumar M
Kumar, Mahesh K
Sachin, P A
Soumya, K
Kotresh, O
Masuku, M C
Keywords: Coumarins;Quinoline;Furan;Thiophene;Anti-bacterial
Issue Date: Jul-2019
Publisher: NISCAIR-CSIR, India
Abstract: Widely distributed in nature, coumarins are one of the more common and well-known representatives of a flavonoid class. Nevertheless, they exhibit a strong and broad variety of biological activities. In the present research study, we describe a series of naphthalene and quinoline, furan and thiophene derivatives fused with a coumarin scaffold. The compounds have been interpreted by IR, GCMS, and NMR spectral studies and evaluated in vitro for their antimicrobial activities against four different pathogenic bacterial strains such as E. coli, P. aeruginosa, K. pneumonia, S. aureus and S. faecalis and fungal strains such as A. flavus, A. fumigatus and B. albicans. The coumarins fused with thiophene ring exhibit promising anti-microbial properties.
Page(s): 842-848
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.58B(07) [July 2019]

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