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Title: Synthesis and characterization of diclofenac impurity-A for the quality control of diclofenac and its formulation as per international compendiums
Authors: Wadhwa, Aparna
Verma, Sandhya
Kumar, Robin
Sahu, Puran L
Singh, Abhishek
Keywords: Diclofenac;Diclofenac impurity-A;Indian pharmacopoeia;Non steroidal anti-inflammatory drug;Symptomatic relief
Issue Date: Jul-2019
Publisher: NISCAIR-CSIR, India
Abstract: Diclofenac is one of the top selling non steroidal anti-inflammatory drug (NSAID). It is available in wide range of dosage form for symptomatic relief of diverse inflammatory conditions. Presence of impurity in drug or drug products is a vital concern now a days for which stringent regulatory guidelines have been implemented to safeguard public health. Under these circumstances, presence of diclofenac impurity-A in diclofenac requires strict quality control to satisfy the specified regulatory limit. Therefore, the objective of the presence study is to synthesize diclofenac impurity-A in the purest form and its subsequent characterization by using a panel of sophisticated analytical techniques to provide as reference standard mentioned in most of the international compendiums including Indian Pharmacopoeia.
Page(s): 855-860
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.58B(07) [July 2019]

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