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JSIR Vol.65 [2006] >
JSIR Vol.65(07) [July 2006] >
| Title: | Process strategies for cephalosporin C fermentation |
| Authors: | Srivastava, Pradeep
Mishra, Punita
Kundu, Subir |
| Keywords: | Acremonium chrysogenum
Cephalosporin C
Batch fermentation
Fed batch fermentation
Flow rates |
| Issue Date: | Jul-2006 |
| Publisher: | CSIR |
| IPC Code: | C12P17/00 |
| Abstract: | Cephalosporin C (CPC), a β-lactam antibiotic, is starting molecule for industrial production of semi synthetic cephalosporins. CPC fermentation has been carried out in Air Lift Reactor (indigenously made up of borosilicate glass) in different fermentation modes i.e., batch and fed batch modes using a mold Acremonium chrysogenum (synn. Cephalosporium acremonium). A definite correlation exists between the antibiotic productivity and flow rate of supplementary feed. Fed batch process was shown to be more efficient than the batch one, and the process in which the lowest supplementary feed flow rate was used resulted in significantly higher antibiotic production. |
| Page(s): | 599-602 |
| ISSN: | 0975-1084 (Online); 0022-4456 (Print) |
| Source: | JSIR Vol.65(07) [July 2006]
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