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Title: Process strategies for cephalosporin C fermentation
Authors: Srivastava, Pradeep
Mishra, Punita
Kundu, Subir
Keywords: Acremonium chrysogenum
Cephalosporin C
Batch fermentation
Fed batch fermentation
Flow rates
Issue Date: Jul-2006
Publisher: CSIR
IPC CodeC12P17/00
Abstract: Cephalosporin C (CPC), a β-lactam antibiotic, is starting molecule for industrial production of semi synthetic cephalosporins. CPC fermentation has been carried out in Air Lift Reactor (indigenously made up of borosilicate glass) in different fermentation modes i.e., batch and fed batch modes using a mold Acremonium chrysogenum (synn. Cephalosporium acremonium). A definite correlation exists between the antibiotic productivity and flow rate of supplementary feed. Fed batch process was shown to be more efficient than the batch one, and the process in which the lowest supplementary feed flow rate was used resulted in significantly higher antibiotic production.
Page(s): 599-602
ISSN: 0975-1084 (Online); 0022-4456 (Print)
Source:JSIR Vol.65(07) [July 2006]

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