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Title: Analytical techniques used to characterize drug-polyvinylpyrrolidone systems in solid and liquid states – An overview
Authors: Chadha, Renu
Kapoor, V K
Kumar, Amit
Keywords: DSC
FTIR
Polyvinylpyrrolidone
Solid dispersion
Solubility
X-Ray diffraction
Issue Date: Jun-2006
Publisher: CSIR
IPC CodeA61J3/07
Abstract: Homogeneous distribution of poorly water-soluble drugs in polyvinylpyrrolidone (PVP), a hydrophilic carrier, is definitely a suitable way to improve the bioavailability of such drugs. However, fundamental knowledge of drug polymer interaction and comprehensive study of the thermal, structural and solubility properties of such binary systems is the prerequisite for the development of useful drug product. The paper reviews physical state, dissolution behavior and elucidation of drug-PVP interaction in solid dispersion using XRD, FTIR, DSC, SEM, hot stage microscopy and NMR. The importance of suitable selection of the system preparation methods have also been demonstrated and emphasis is laid on the potential methods for the industrial production of solid dispersions.
Page(s): 459-469
ISSN: 0975-1084 (Online); 0022-4456 (Print)
Source:JSIR Vol.65(06) [June 2006]

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