NISCAIR Online Periodicals Repository

Research Journals >
Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.46B [2007] >
IJC-B Vol.46B(03) [March 2007] >

Title: Synthesis and characterization of new quinazolines as potential antimicrobial agents
Authors: Desai, N C
Shihora, P N
Moradia, D L
Keywords: Quinazoline
Antibacterial activity
Antifungal activity
Issue Date: Mar-2007
Publisher: CSIR
IPC CodeInt.Cl.⁸
Abstract: Ethyl 4-[2-(2-chlorophenyl)-4-oxo-3-hydroquinazolin-3yl]benzoate 1 which reacts with hydrazine hydrate in presence of methanol resulted into N-amino{4-[2-(2-chlorophenyl)-4-oxo(3-hydroquinazolin-3-yl)phenyl}carboxamide 2. Compound 2 on treatment with aryl isothiocyanates in presence of acetone is converted into aryl-N-{[({4-[2- (2-chlorophenyl)-4-oxo(3-hydroquinazolin-3-yl)]phenyl}carbonylamino)amino]thioxo methyl}amides 3. Compound 3, in presence of sulphuric acid has yielded aryl-N-(5-{4-[2-(2-chlorophenyl)-4-oxo(3-hydroquinazolin-3-yl)]phenyl}(1,3,4,thiadiazol-2-yl))amides 4a-l. Newly synthesized compounds 4a-l have been screened for their antibacterial and antifungal activities on Eschericia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Staphylococcus pyogenes, C. albicans, A. niger and A. clavatus.
Page(s): 550-553
ISSN: 0376-4699
Source:IJC-B Vol.46B(03) [March 2007]

Files in This Item:

File Description SizeFormat
IJCB 46B(3) (2007) 550-553.pdf131.38 kBAdobe PDFView/Open
 Current Page Visits: 944 
Recommend this item


Online Submission of Articles |  NISCAIR Website |  National Knowledge Resources Consortium |  Contact us |  Feedback

Disclaimer: NISCAIR assumes no responsibility for the statements and opinions advanced by contributors. The editorial staff in its work of examining papers received for publication is helped, in an honorary capacity, by many distinguished engineers and scientists.

CC License Except where otherwise noted, the Articles on this site are licensed under Creative Commons License: CC Attribution-Noncommercial-No Derivative Works 2.5 India

Copyright © 2015 The Council of Scientific and Industrial Research, New Delhi. All rights reserved.

Powered by DSpace Copyright © 2002-2007 MIT and Hewlett-Packard | Compliant to OAI-PMH V 2.0

Home Page Total Visits: 132770 since 01-Sep-2015  Last updated on 20-May-2016Webmaster: