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dc.contributor.authorMane, Ananda-
dc.contributor.authorKamat, Siddharth-
dc.contributor.authorPatil, Audumbar-
dc.contributor.authorSalunkhe, Rajashri-
dc.identifier.issn0975-0983(Online); 0376-4699(Print)-
dc.description.abstractThe concomitant exploitation of two of the green chemistry tools viz., sonication and biocatalysis is reported here for the synthesis of natural alkaloid, tryptanthrin (indolo[2,1-b]quinazoline-6,12-dione). High intensity ultrasound has been applied to facilitate the release of enzymes by disruption of cells of baker’s yeast (Saccharomyces cerevisae) as a biocatalyst. The coupled system is an excellent instance of enhanced rate of biocatalyzed reaction and has proven to be a green alternative to existing methodologies for the synthesis of tryptanthrins. The present method is bestowed with merits such as mild and clean reaction conditions, operational simplicity, tolerance for a wide variety of substituents, green aspects through the avoidance of toxic metal catalysts and highly selective conversion with no byproducts.en_US
dc.publisherNISCAIR-CSIR, Indiaen_US
dc.rights CC Attribution-Noncommercial-No Derivative Works 2.5 Indiaen_US
dc.sourceIJC-B Vol.58B(06) [June 2019]en_US
dc.subjectBaker's yeasten_US
dc.titleBiocatalyst mediated synthesis of tryptanthrins performed under ultrasonicationen_US
Appears in Collections:IJC-B Vol.58B(06) [June 2019]

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