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Title: Biocatalyst mediated synthesis of tryptanthrins performed under ultrasonication
Authors: Mane, Ananda
Kamat, Siddharth
Patil, Audumbar
Salunkhe, Rajashri
Keywords: Ultrasonication;Tryptanthrin;Alkaloids;Biosynthesis;Baker's yeast
Issue Date: Jun-2019
Publisher: NISCAIR-CSIR, India
Abstract: The concomitant exploitation of two of the green chemistry tools viz., sonication and biocatalysis is reported here for the synthesis of natural alkaloid, tryptanthrin (indolo[2,1-b]quinazoline-6,12-dione). High intensity ultrasound has been applied to facilitate the release of enzymes by disruption of cells of baker’s yeast (Saccharomyces cerevisae) as a biocatalyst. The coupled system is an excellent instance of enhanced rate of biocatalyzed reaction and has proven to be a green alternative to existing methodologies for the synthesis of tryptanthrins. The present method is bestowed with merits such as mild and clean reaction conditions, operational simplicity, tolerance for a wide variety of substituents, green aspects through the avoidance of toxic metal catalysts and highly selective conversion with no byproducts.
Page(s): 691-697
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.58B(06) [June 2019]

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