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|Title:||Biocatalyst mediated synthesis of tryptanthrins performed under ultrasonication|
|Abstract:||The concomitant exploitation of two of the green chemistry tools viz., sonication and biocatalysis is reported here for the synthesis of natural alkaloid, tryptanthrin (indolo[2,1-b]quinazoline-6,12-dione). High intensity ultrasound has been applied to facilitate the release of enzymes by disruption of cells of baker’s yeast (Saccharomyces cerevisae) as a biocatalyst. The coupled system is an excellent instance of enhanced rate of biocatalyzed reaction and has proven to be a green alternative to existing methodologies for the synthesis of tryptanthrins. The present method is bestowed with merits such as mild and clean reaction conditions, operational simplicity, tolerance for a wide variety of substituents, green aspects through the avoidance of toxic metal catalysts and highly selective conversion with no byproducts.|
|Appears in Collections:||IJC-B Vol.58B(06) [June 2019]|
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|IJCB 58B(6) 691-697.pdf||Main Article||200.46 kB||Adobe PDF||View/Open|
|IJCB 58B(6) 691-697_Suppl Data.pdf||Supplementary Data||4.08 MB||Adobe PDF||View/Open|
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